| Distance from | | Distance from |
| Toronto | | Coboconk |
| | | |
| 0.0 | Highway 401 Junction (Toronto) | 129.2 |
| | | |
| 10.1 | Highway 7 Junction (Markham) | 119.1 |
| | | |
| 14.2 | Major Mackenzie Drive (MTO Ownership Starts) | 115.0 |
| | | |
| 20.3 | Old Highway 47 Junction (To Stouffville) | 108.9 |
| | | |
| 24.5 | Highway 47 Junction (Bloomington Road) | 104.7 |
| | | |
| 34.9 | York Road 31 Junction (Davis Drive) | 94.3 |
| | | |
| 49.4 | York Road 32 Junction (Ravenshoe Road) | 79.8 |
| | | |
| 58.2 | York Road 9 Junction (To Sutton) | 71.0 |
| | | |
| 71.9 | Durham Road 23 Junction (Lakeridge Road) | 57.3 |
| | | |
| 77.8 | Former Highway 48B Junction (Side Road 17) | 51.4 |
| | | |
| 80.5 | Highway 12 South Junction (Current North Terminus of Highway 48) | 48.7 |
| | | |
| 86.6 | Durham Road 15 Junction (Beaverton) | 42.6 |
| | | |
| 93.2 | Highway 12 North Junction (To Orillia) | 36.0 |
| | | |
| 102.9 | Highway 46 Junction (Bolsover) | 26.3 |
| | | |
| 110.2 | Highway 503 Junction (Kirkfield) | 19.0 |
| | | |
| 114.7 | Highway 505 Junction (Victoria Road) | 14.5 |
| | | |
| 129.2 | Highway 35 Junction (Coboconk) | 0.0 |
