| Distance from | | Distance from |
| Fort Erie | | Toronto |
| | | |
| 0.0 | Peace Bridge Plaza - Fort Erie (Start of QEW) | 144.1 |
| | | |
| 0.2 | Central Avenue Interchange | 143.9 |
| | | |
| 1.1 | Exit #1 - Concession Road Interchange | 143.0 |
| | | |
| 2.1 | Exit #2 - Thompson Road Interchange | 142.0 |
| | | |
| 4.5 | Exit #5 - Gilmore Road Interchange | 139.6 |
| | | |
| 6.5 | Exit #7 - Bowen Road Interchange | 137.6 |
| | | |
| 11.1 | Old Townline Road Overpass | 133.0 |
| | | |
| 12.0 | Exit #12 - Netherby Road Interchange | 132.1 |
| | | |
| 15.2 | Exit #16 - Sodom Road Interchange | 129.0 |
| | | |
| 21.9 | Exit #21 - Lyons Creek Road Interchange | 122.3 |
| | | |
| 26.3 | Exit #27 - McLeod Road Interchange | 117.8 |
| | | |
| 28.4 | Lundy's Lane Underpass | 115.7 |
| | | |
| 29.2 | Exit #30 - Highway 420 Interchange | 114.9 |
| | | |
| 31.2 | Exit #32 - Thorold Stone Road Interchange | 113.0 |
| | | |
| 33.6 | Exit #34 - Mountain Road Interchange | 110.5 |
| | | |
| 36.0 | Exit #37 - Highway 405 Interchange | 108.1 |
| | | |
| 37.4 | Exit #38 - Glendale Avenue Interchange | 106.8 |
| | | |
| 41.3 | St. Catharines City Limits (Welland Canal) | 102.8 |
| | | |
| 42.3 | Niagara Street Service Roads Interchange | 101.8 |
| | | |
| 42.7 | Welland Avenue Underpass | 101.4 |
| | | |
| 43.3 | Exit #44 - Niagara Street Interchange | 100.8 |
| | | |
| 45.0 | Exit #46 - Lake Street Interchange | 99.1 |
| | | |
| 46.3 | Exit #47 - Ontario Street Interchange | 97.9 |
| | | |
| 47.0 | Exit #48 - Martindale Road Interchange | 97.1 |
| | | |
| 47.7 | Exit #49 - Highway 406 Interchange | 96.5 |
| | | |
| 49.9 | Exit #51 - Seventh Street Interchange | 94.3 |
| | | |
| 54.1 | Exit #55 - Jordan Road Interchange | 90.1 |
| | | |
| 56.9 | Exit #57 - Victoria Avenue Interchange | 87.2 |
| | | |
| 63.7 | Exit #64 - Ontario Street Interchange | 80.4 |
| | | |
| 67.5 | Exit #68 - Bartlett Avenue Interchange | 76.6 |
| | | |
| 70.0 | Exit #71 - Maple Avenue Interchange | 74.1 |
| | | |
| 73.6 | Exit #74 - Casablanca Boulevard Interchange | 70.5 |
| | | |
| 77.1 | Exit #78 - Fifty Road Interchange | 67.0 |
| | | |
| 82.2 | Exit #83 - Fruitland Road Interchange | 61.9 |
| | | |
| 87.3 | Exits #88 & #89 - Highway 20 & Red Hill Valley Parkway | 56.8 |
| | | |
| 88.9 | Exit #90 - Nikola Tesla Boulevard Interchange | 55.2 |
| | | |
| 92.7 | Exit #93 - Highway 7189 (Eastport Drive) Interchange | 51.4 |
| | | |
| 93.3 | Hamilton-Burlington City Limits | 50.1 |
| | | |
| 94.9 | Exit #97 - North Shore Boulevard Interchange | 49.2 |
| | | |
| 97.3 | Exit #99 - Fairview Street Interchange | 46.8 |
| | | |
| 98.3 | Exit #100 - Freeman Interchange (Hwy 403 West & Hwy 407 ETR) | 45.8 |
| | | |
| 99.1 | Exit #101 - Brant Street Interchange | 45.0 |
| | | |
| 101.0 | Exit #102 - Guelph Line Interchange | 43.1 |
| | | |
| 103.1 | Exit #105 - Walkers Line Interchange | 41.1 |
| | | |
| 105.1 | Exit #107 - Appleby Line Interchange | 39.0 |
| | | |
| 107.1 | Exit #109 - Burloak Drive Interchange | 37.0 |
| | | |
| 109.3 | Exit #111 - Highway 25 (Bronte Road) Interchange | 34.8 |
| | | |
| 111.4 | Exit #113 - Third Line Interchange | 32.7 |
| | | |
| 114.5 | Exit #116 - Dorval Drive Interchange | 29.6 |
| | | |
| 116.6 | Exit #118 - Trafalgar Road Interchange | 27.5 |
| | | |
| 118.1 | Exit #119 - Royal Windsor Drive Interchange | 26.0 |
| | | |
| 121.2 | Exit #123 - Hwy 403 East & Ford Drive Interchange | 22.9 |
| | | |
| 122.6 | Exit #124 - Winston Churchill Boulevard Interchange | 21.5 |
| | | |
| 125.0 | Exit #126 - Erin Mills Parkway Interchange | 19.1 |
| | | |
| 128.9 | Exit #130 - Mississauga Road Interchange | 15.2 |
| | | |
| 131.0 | Exit #132 - Highway 10 (Hurontario Street) Interchange | 13.1 |
| | | |
| 133.1 | Exit #134 - Cawthra Road Interchange | 11.0 |
| | | |
| 135.0 | Exit #136 - Dixie Road Interchange | 9.1 |
| | | |
| 136.7 | Exit #138 - Evans Avenue Interchange | 7.4 |
| | | |
| 137.8 | Exit #139 - Highway 427 Interchange (Current End of QEW) | 6.3 |
| | | |
| 139.8 | Exit #141 - Kipling Avenue Interchange | 4.4 |
| | | |
| 140.7 | Exit #142 - Islington Avenue Interchange | 3.4 |
| | | |
| 142.8 | Exit #144 - Park Lawn Road Interchange | 1.3 |
| | | |
| 143.3 | Exit #145 - Lakeshore Boulevard Interchange | 0.8 |
| | | |
| 144.1 | Humber River Bridge (End of QEW prior to 1997) | 0.0 |